MUC1/ EMA/ CD227 MBS438402 from MyBioSource.com

Product Specs
ItemMUC1/ EMA/ CD227
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS438402
Quantity0.1 mg
ApplicationsELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
Conjugate/TagUnconjugated
ReactivityHuman
TargetMUC1
IsotypeIgG2a kappa
Molecular Weight265-400kDa
CloneE29
HostMouse
ImmunogenIn Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit and the C-terminal beta subunit. The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinomas. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver
NCBI Full Gene Namemucin 1, cell surface associated
NCBI Gene AliasesADMCKD, PUM, MUC-1, EMA, PEMT, MCKD1, MUC1/ZD, MCD, KL-6, MAM6, H23AG, PEM, CA 15-3, CD227, ADMCKD1, MUC-1/X, MUC-1/SEC, MCKD
ClonalityMonoclonal